Sign Out
Symptoms: Indapamide has been found to be free of toxicity at up to 40 mg, i.e. 27 times the therapeutic dose.
Signs of acute poisoning take the form above all of water/electrolyte disturbances (hyponatraemia, hypokalaemia). Clinically, there is the possibility of nausea, vomiting, hypotension, cramps, dizziness, drowsiness, confusion, polyuria or oliguria possibly to the point of anuria (by hypovolaemia).
Management: Initial measures involve the rapid elimination of the ingested substance(s) by gastric wash-out and/or administration of activated charcoal, followed by restoration of water/electrolyte balance in a specialised centre.
